We stand today on the threshold of a new understanding of cancer. Primarily through the powerful tools of molecular biology, unified hypotheses explaining the origins of the disease are emerging and rapidly being validated. This volume, which presents the latest findings from laboratories throughout the world on the role of RNA tumor viruses in cancer, is a celebration of these achievements and a prediction of further progress leading ultimately to the control of the disease. It is important in this context to recall the natural history or life cycle of RNA cancer virology. From the earliest...
We stand today on the threshold of a new understanding of cancer. Primarily through the powerful tools of molecular biology, unified hypotheses explai...
Liver-Directed Therapy for Primary and Metastatic Liver Tumors is a comprehensive examination of tumors of the liver. It provides a unique multi-modality approach to management of all types of primary and secondary liver tumors. The biology of liver cancers, state of the art radiologic imaging and novel, non-surgical interventional strategies are given. There is an in depth analysis of surgical options including transplantation, resection, interstitial ablation techniques and liver-directed chemotherapy for hepatocellular carcinoma, bile duct cancers, and colorectal and...
Liver-Directed Therapy for Primary and Metastatic Liver Tumors is a comprehensive examination of tumors of the liver. It provides a unique mu...
Paul Sugarbaker and his colleagues have persevered in the study and treat ment of peritoneal carcinomatosis. The peritoneal cavity has many unique and incompletely appreciated properties. These properties, coupled with the biologic behavior of many cancers, results in the seeding and growth of these cancers on the peritoneum. Many of these cancers remain localized to the peritoneum only, never metastasizing to other sites. One possible reason for this may be the obstruction of the afferent lymphatics on the undersurface of the diaphragm. The mucopolysaccharides produced by many of these...
Paul Sugarbaker and his colleagues have persevered in the study and treat ment of peritoneal carcinomatosis. The peritoneal cavity has many unique and...
Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who study rodent models of the disease and to those who study the cellular and molecular basis of human breast cancer. The first section of the book is devoted to new mouse models of mammary...
Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advan...
Leukemia is a malignant disease which continues to play a cutting edge role in the discovery of new basic knowledge about the malignant process and about the potential for controlling these malignant diseases. Molecular Genetics and Therapy of Leukemia presents contributions by leading investigators and scientific contributors to such topics as chromosome 16, chromosome 5, the BCL-2 gene, 11q23 breakpoint leukemias, the p-53 suppressor gene and oncogene, hematopoietic stem cells, cytokines, detection of minimal residual disease in acute lymphoblastic leukemia, autologous marrow...
Leukemia is a malignant disease which continues to play a cutting edge role in the discovery of new basic knowledge about the malignant process and ab...
Screening for cancer is an important focus of cancer control. Yet screening, as it involves administering a test to large segments of the population deemed to be at risk for the disease of interest, is potentially a major consumer of scarce health care resources. In addition, the benefits sought from cancer screening, particularly reduction in mortality from the disease, are not always realized, either for biological or organizational reasons. Thus, the paradigm that early detection must always be beneficial', taught to health care professionals, and publicized widely through the media to the...
Screening for cancer is an important focus of cancer control. Yet screening, as it involves administering a test to large segments of the population d...
Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in...
Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to dr...
Pediatric and Adolescent Osteosarcoma provides a historical review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in Epidemiology and Etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age group, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of...
Pediatric and Adolescent Osteosarcoma provides a historical review of the nature of osteosarcoma and the conflict that accompanied the introduction...
Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics.
Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium.
This updated second edition includes exciting new advances in ovarian cancer detection and...
Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to ach...
Endocrine Neoplasia is a comprehensive, updated, and clearly-written text covering the diseases for which endocrine surgical expertise is often needed. We look towards advances in the science and the art of endocrine surgery to continuously improve outcomes for our patients. The goal of this text was to provide a detailed description of both the underlying science of disease as well as the art of clinical management.
The book is divided into five sections addressing neoplasms of the thyroid, parathyroid, adrenal gland, neuroendocrine pancreas, and multiple endocrine neoplasia....
Endocrine Neoplasia is a comprehensive, updated, and clearly-written text covering the diseases for which endocrine surgical expertise is often nee...
