A great deal of experimental, clinical and epidemiological data have been gathered to confirm the strict and causal correlation between plasma lipoproteins and coronary heart disease. However, as usually happens in research, many more interesting issues are being studied, opening new fields of research for the future. These new advances, together with the combined efforts of cell biologists and lipoprotein chemists, have set the pace for an exciting period of research and clinical applications of diets and drugs affecting plasma and cell lipids. This volume, which includes the work of many of...

"Et moi, ..., si j'avait Sll comment en revenir. One sennce mathematics has rendered the human race. It has put common sense back je n'y serais point alle.' Jules Verne whe," it belongs, on the topmost shelf next to the dusty canister labelled 'discarded non- The series is divergent; therefore we may be smse'. able to do something with it. Eric T. Bell O. Heaviside Mathematics is a tool for thought. A highly necessary tool in a world where both feedback and non linearities abound. Similarly, all kinds of parts of mathematics serve as tools for other parts and for other sciences. Applying a...

In children, the central nervous system tumors complished through advances in the three main are exceeded in incidence only by leukemia and antineoplastic therapeutic modalities-surgery, are more common than any of the other malig radiation therapy, and chemotherapy. Improve nancies of childhood. Childhood central nervous ments in neurosurgical technique concomitant system tumors encompass a range of histo with improvements in anesthesia and periopera logic varieties from the histologically benign tive supportive care have resulted in decreased appearing pilocytic astrocytoma to the extremely...

Twenty years have elapsed since cytoplasmic proteins exhibiting high-affinity binding of long-chain fatty acids were first identified (Ockner et al., Science 177:56-58, 1972). These cellular fatty acid-binding proteins (FABPs) are now well established to comprise a ligand-defined group of macromolecules belonging to a family of cytoplasmic lipid binding proteins. Unique features of the FABPs are the existence of distinct types of FABP and that these are found in a variety of tissues in remarkable abundance, with some cells expressing more than one type. The physiological significance of the...

In recent years excellent progress has been the study of these disorders in the future. made in the development of improved Recently freeze fracture techniques have cytochemical and ultrastructural tech also been employed in the study of normal niques for electron microscopy in hematol and leukemic lymphocytes and much new ogy and in particular in leukemia and information concerning leukemic cell lymphoma. Subtypes of these disorders, membranes may be obtained from the use which are essentially classified according to of this technique in the future. cell phenotype and the degree of matura...

As in CANCER CHEMOTHERAPY 1, this volume brings to the reader highlights in three different areas of cancer therapeutics: new concepts and models; drug classes; and clinical settings. Topics were chosen because of their timeliness or probable current impact in cancer treatment. Authors were selected on the basis of their ability to provide a critical overview of specific subjects and their involvement in original work. I shall review the aims of this second volume, and then elaborate on the scope of its con tents. The principal aim of the volumes on cancer chemotherapy in the' Cancer...

from combining radiation with a molecular targeted agent namely cetuximab, a recombinant mouse/human chimeric monoclonal antibody against the Epidermal Growth Factor (EGF) receptor 4] Astsaturov, Cohen and Harari present a more indepth review of the biology of the EGF Receptor and its signaling pathway in Chap. 7 as a potential target in combination with fractionated radiotherap y for head and neck squamous cell carcinoma (HNSCC). A flurry of agents are under de velopment for targeting EGFR and in March 2006, the US Food and Drugs Administration approved cetuximab combined with radiation as...

Many comprehensive text books have been written about the common hematologic malignancies. However, every practicing hematologist/oncologist or primary care physician intermittently encounters patients with uncommon or rare hematologic malignancies. Information concerning these diseases, and particularly regarding their management, is extremely difficult to find. Physicians will commonly spend a substantial period of time searching the medical literature for help or will call a colleague who may have greater expertise in the area.

Rare Hematological Malignancies covers malignant...

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure...

Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation.
Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of...