Molecular Genetics and Therapy of Leukemia

ISBN-13: 9781461285373 / Angielski / Miękka / 2011 / 334 str.

Emil J. Freireich; Hagop Kantarjian

Opis

Leukemia is a malignant disease which continues to play a cutting edge role in the discovery of new basic knowledge about the malignant process and about the potential for controlling these malignant diseases. Molecular Genetics and Therapy of Leukemia presents contributions by leading investigators and scientific contributors to such topics as chromosome 16, chromosome 5, the BCL-2 gene, 11q23 breakpoint leukemias, the p-53 suppressor gene and oncogene, hematopoietic stem cells, cytokines, detection of minimal residual disease in acute lymphoblastic leukemia, autologous marrow transplantation, the retinoblastoma gene, allogeneic bone marrow transplant and chemotherapy of acute lymphoblastic leukemia.

Spis treści

Introduction. 1. Molecular Genetics of Inversion 16 Leukemia: Implications for Leukemogenesis; D.F. Claxton, et al. 2. Deletion of Chromosome 5 (5q-) in Leukemia: Current Knowledge; L. Nagarajan. 3. Bcl-2 Family Proteins and the Regulation of Programmed Cell Death in Leukemia and Lymphoma; J.C. Reed, et al. 4. MLL Fusion Genes in the 11q23 Acute Leukemias; J.R. Downing, A. T. Look. 5. The c-myb Protooncogene: A Novel Target for Human Gene Therapy; A.M. Gewirtz. 6. The Role of p53 in Malignancy; F.J. Keith, N.H. Russell. 7. Primitive Hematopoietic Stem and Progenitor Cells in Human Umbilical Cord Blood: An Alternative Source of Transplantable Cells; H.E. Broxmeyer. 8. Detection of Minimal Residual Disease in ALL: Biology, Methods and Applications; W.M. Roberts, et al. 9. Interleukin-6: Biologic Properties and Role in Lymphoproliferative Disorders; J.F. Seymour, R. Kurzrock. 10. Autologous Bone Marrow Transplantation for Leukemia and Lymphoma; K. van Besien, S. Giralt. 11. Retinoblastoma Gene in Malignancy; L.C. Pagliaro. 12. Treatment of Relapse After Allogeneic Bone Marrow Transplantation; S.A. Giralt, K. van Besien. 13. Acute Lymphocytic Leukemia. A Comprehensive Review with Emphasis on Biology and Therapy; J.E. Cortes, et al.