Rickettsial diseases have affected humanity since the dawn of civilization. Despite the advent of effective antibiotic therapy, humans continue to be afflicted by rickettsial diseases, which still often go undiagnosed because of their protean clinical manifestations.
During the past decade, several major developments have occurred in rickettsiology. With the advent of the newly emerging infections caused by a number of rickettsias, the re-emerging of old pathogenic species of rickettsias that cause both old and new syndromes has helped redefine the level of rickettsial pathogenicity....
Rickettsial diseases have affected humanity since the dawn of civilization. Despite the advent of effective antibiotic therapy, humans continue to be ...
Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. It is essential that we gain a broader understanding of the factors that regulate the biology of stem cells: their ability for self-renewal, differentiation, and plasticity, as well as the differences between embryonic and adult stem cells. And to learn whether stem cells can be manipulated to replace cells in diseased tissues depends on better understanding their normal developmental properties.
This volume offers contributions from numerous interdisciplinary areas bridging...
Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. It is essential that we gain a broader unders...
The past few years have brought an influx of new information into the field of male reproduction. Several laboratories have been able to apply the genomics approach to gene expression in the male, revealing previously unknown patterns of gene expression and gene products that were localized in male reproductive tract tissues and cells for the first time. These discoveries paved the way for the next wave, an opportunity to analyze male reproductive biology and the processes by which sperm are formed in the seminiferous tubule and androgen is synthesized in the interstitium of the testis.
The past few years have brought an influx of new information into the field of male reproduction. Several laboratories have been able to apply the gen...
Researchers from diverse research communities in cognitive neuroscience, clinical neuroscience, MR-diffusion tensor imaging, and algorithm development have contributed articles that explore the potential for diffusion tensor imaging (DTI) to measure and model white matter tracts in the human brain.
The most advanced uses of diffusion tensor-weighted magnetic resonance imaging for modeling white matter neural connectivity and tractography are assessed; in addition, the authors discuss (1) methods for integrating DTI of white matter into cognitive and clinical neuroscience data and...
Researchers from diverse research communities in cognitive neuroscience, clinical neuroscience, MR-diffusion tensor imaging, and algorithm development...
The basic phenomena of intra- and intercellular communication and the transport signals within and between the cells controlling cardiac function are described and discussed in this volume. The amazing synchronization of millions of cells and billions of nanoscale molecular motors, ion gates, and ion pumps assure normal cardiac function; whereas disharmony and local transport and signal disruptions are the forecasters, and eventual causes, of pathologic conditions and heart failure.
Although this volume concentrates on basic phenomena, strong emphasis is given to the related...
The basic phenomena of intra- and intercellular communication and the transport signals within and between the cells controlling cardiac function are ...
This volume provides a snapshot of the state of the art of oculomotor and vestibular research, focusing on the bridge between laboratory and clinical research and the interdisciplinary relationships among ophthalmology, neurology, and otology.
A common theme in contemporary neuroscience is how the brain learns and adapts at the most basic levels and how patients can benefit from this type of research. Recent advances in the physiology and anatomy of the eye muscles and other orbital structures and their relevance to strabismus sets the stage in the first section. Then, attention...
This volume provides a snapshot of the state of the art of oculomotor and vestibular research, focusing on the bridge between laboratory and clinical ...
As life expectancy has increased, so has the incidence of neurodegenerative diseases, particularly those associated with aging. Contributing to increased life expectancy is increased survival following brain injury, stroke, and procedures such as heart surgery, but these events can impair neurological function.
The wide range of contributions to this volume, from a detailed paper on the use of gene therapy in combination with hypothermia for the treatment of cerebral ischemia to a comprehensive poster describing the role of anesthetic agents in neurotoxicity during development and...
As life expectancy has increased, so has the incidence of neurodegenerative diseases, particularly those associated with aging. Contributing to increa...
The potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools are explored in this volume, which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides. The focus is on antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG immune modulatory oligonucleotides.
Specific chapters address designing better siRNAs, splice switching oligonucleotides, selective delivery of oligonucleotides, and medicinal drugs by receptor-mediated endocytosis, development of a function overriding siRNA silencing...
The potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools are explored in this v...
Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to replace the all-purpose remedies of the past 30 years. This volume, which draws on the principles of immunology presented in Volume 1050 (Autoimmunity: Concepts and Diagnosis at the Cutting Edge), extends these concepts to the realm of clinical findings and current therapy for many autoimmune and connective tissue disorders.
Both organ-specific and organ-nonspecific diseases are covered, and one section is entirely focused on...
Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to...
