Wyniki wyszukiwania:

Avec plus de 3% de la population mondiale actuellement infectA(c)e, l'hA(c)patite C est une des plus graves maladies infectieuses. La recherche et la mise au point de nouvelles molA(c)cules, capables de traiter ou de conduire A l'A(c)radication de cette maladie, sont donc d'une grande importance. Nous prA(c)sentons dans ce manuscrit le dA(c)veloppement et la synthA]se de deux sA(c)ries de dinuclA(c)osides phosphoramidates de type 2'-O-mA(c)thylguanosin-3'-yl-cytidin-5'-yle et de type 2'-O-mA(c)thylguanosin-3'-yl-3'-dA(c)soxycytidin-5'-yle, utilisA(c)s comme inhibiteurs de la polymA(c)rase...

The series is devoted to the publication of high-level monographs and specialized graduate texts which cover the whole spectrum of applied mathematics, including its numerical aspects. The focus of the series is on the interplay between mathematical and numerical analysis, and also on its applications to mathematical models in the physical and life sciences.

The aim of the series is to be an active forum for the dissemination of up-to-date information in the form of authoritative works that will serve the applied mathematics community as the basis for further research.