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This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical application which took place from August 23 25, 2006 in Kyiv and from August 26 31, 2006 in Simeiz, Ukraine. The meeting was devoted to hot topics in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of...

Helper T cells activate a set of lymphokine genes upon recognition of antigens presented in the context of the major histocompatibility complex on antigen presenting cells (Arai et al., 1986; Miyajima et al., 1988). Activation of T cells proceeds in two distinct stages. The flrst step is triggered by binding of an antigen to the T cell antigen receptor/CD3 complex that leads to the activation of protein kinase C (PKC) and an increase in intracellular Ca2+. This step, which is substituted by phorbol ester and calcium ionophore (Weiss et al., 1984), possibly proceeds through GTP binding protein...

This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical application which took place from August 23 25, 2006 in Kyiv and from August 26 31, 2006 in Simeiz, Ukraine. The meeting was devoted to hot topics in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of...