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The objective was to formulate Silymarin into nanostructured lipid carriers (NLC) to enhance its sun screening efficacy and safety. NLC of Silymarin were prepared by the high pressure homogenization. The study design involves the investigation of the effect of two independent variables namely ratio of solid lipid and liquid lipid concentration (60:40, 70:30, 80:20 with respect to total lipid), and Tween 80 concentration (3%, 4% and 5%) on Surface morphology by SEM analysis, FTIR, DSC, particle size (PS), entrapment efficiency (%EE) and in-vitro drug release after 24 h. The prepared NLC were...

Ranitidine Hydrochloride, an Histamine 2 receptor antagonist, can be absorbed in upper part of GIT including stomach and proximal intestine. Moreover, when it comes in contact with colonic media, degradation starts. Low density floating tablets of Ranitidine Hydrochloride were prepared using polyethylene oxide (POLYOX WSR N 60 K) as a polymer and L-Menthol as a sublimating material. Sublimation technique, generally used for mouth dissolving tablet, was used to make porous tablet that have minimal lag time just within a fraction of time and floated for more than 24 h. Moreover, tablet floating...

The objective of present work was to check the effect of hydrophilic polymers on the release of Clozapine from matrix tablet. Hydrophilic polymers were used to control the release of drug. Matrix tablets were prepared using direct compression method. HPMC K 100 M, Guar gum and Sodium CMC used as release retardant polymers. Polymers were used in the ratio of 1:3, 1:4, 1:5 and 1:8. Rate of drug release decreased as the polymer ratio increased. The level of polymer ratio also had an effect on swelling index showing a linear relationship. At 1:8 (drug: polymer) ratio with HPMC K 100 M, tablets...