Wyniki wyszukiwania:

Sumatriptan, an antimigraine drug has poor bioavailability (15%) due to hepatic first pass metabolism. The aim of the present investigation was to develop sumatriptan loaded solid lipid nanoparticles (SLN) for improving oral bioavailability. Sumatriptan loaded solid lipid nanoparticles was developed by emulsification - ultrasonication method. A 32 factorial design was employed: two factors such as drug: lipid ratio and lipid: surfactant ratio were the independent variables used. Parameters investigated included particle size, polydispersity index (PDI), zeta potential, % entrapment efficiency...

The objective of present work was to check the effect of hydrophilic polymers on the release of Clozapine from matrix tablet. Hydrophilic polymers were used to control the release of drug. Matrix tablets were prepared using direct compression method. HPMC K 100 M, Guar gum and Sodium CMC used as release retardant polymers. Polymers were used in the ratio of 1:3, 1:4, 1:5 and 1:8. Rate of drug release decreased as the polymer ratio increased. The level of polymer ratio also had an effect on swelling index showing a linear relationship. At 1:8 (drug: polymer) ratio with HPMC K 100 M, tablets...