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Quality of Life (QoL) outcomes or Person/Patient Reported Outcome Measures (PROMs) are now frequently being used in randomised controlled trials (RCTs) and observational studies. This book provides a practical guide to the design, analysis and interpretation of studies that use such outcomes.

QoL outcomes tend to generate data with discrete, bounded and skewed distributions. Many investigators are concerned about the...

Evidence-Based Neurosurgery: An Introduction will teach the practitioner to employ evidence-based approaches to common problems in neurosurgery. The book begins with a review of the concepts and techniques involved in the practice of evidence-based medicine, including the basics of critical analysis using methodologically rigorous evidence-synthesis techniques. The second part of the text provides useful examples of the use of this critical analysis for common clinical situations, such as stent placement, managing infection, metastases, craniocerebral trauma, cervical spine trauma,...

Written by two researchers with extensive experience in the field, this book presents a complete guide to the design, analysis and reporting of cluster randomised trials. It spans a wide range of applications: trials in developing countries, trials in primary care, trials in the health services. A key feature is the use of R code and code from other popular packages to plan and analyse cluster trials, using data from actual trials. The book contains clear technical descriptions of the models used, and considers in detail...