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Two pivotal aspects of the IL-33 system are characterized in this study: First the composition and function of the IL-33 receptor complex on IL-33 responder cells and second the generation of biologically active IL-33 by the IL-33 producer cell. IL-33 binds to the IL-33 receptor -chain (ST2) and as is shown here, this results in the recruitment of interleukin-1 receptor accessory protein (IL-1RAcP) as the co-receptor. The IL-33-dependent interaction of membrane bound and soluble form of IL-1RAcP and IL-33R -chain was demonstrated in co-immunoprecipitation assays. Common notion in the field is...

Throughout this book, present study aimed to create interest and guide the readers about achievement of trade liberalization among developing countries. It is also aimed to analyze, how developing countries can enhance their intra-regional trade based on Regional Trade Agreements (RTAs), and up to what extend a dynamic approach (i.e. Pattern of comparative advantage) can be fruitful in identification of sectors/products having export potential among concern economies. Accordingly, our finding revealed that trade performance can be improve due to formation of RTAs (i.e. Preferential or Free...