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In this book, leading figures in the field of Developmental Origins of Health and Disease provide up-to-date information from human clinical trials, cohorts, and animal physiology experiments to reveal the interdependence between parental obesity and health of the offspring. Obesity of the mother and father produces obesity in their offspring, so we are caught up in an intergenerational cycle, which means that even our children's future health is in peril. This book gives a timely and much-needed synthesis of the mechanisms, potential targets of future interventions, and the challenges...

This is a complete facsimile edition of fourteen autograph letters of John Donne that are among the greatest treasures of the Folger Library. The letters, dating from February and March 1602, relate to Donne's clandestine marriage to Anne More and are addressed to his father-in-law, Sir George More, and to Sir Thomas Egerton, the lord keeper, who was also Donne's employer.

The text of a letter provides one part of the story, while its very tangibility -- the ancient folds, the grime and fingerprints deposited by the writer, deliverer, and readers, the broken seals, the ink blots, the...