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The first line anti-tuberculosis drugs are known to cause dose related adverse drug reactions like peripheral neuritis and hepatotoxicity. The risk of getting peripheral neuritis have been avoided through a concomitant administration of pyridoxine; while hepatotoxicity remains to be a major adverse effect of anti- tuberculosis therapy. Research findings state reduction in the incidence of hepatotoxicity by exploring a potential link between biopharmaceutical pattern of anti-tuberculosis drugs and genetic polymorphism of the enzymes metabolizing them. Reportedly a significant correlation has...

Pregnancy is a special physiological condition where drug treatment presents a special concern because the physiology of pregnancy affects the pharmacokinetics of medications used and certain medications can reach the fetus and cause harm. Drug Utilization Review is an authorized, structured, ongoing review of healthcare provider prescribing, pharmacist dispensing, and patient use of medication. They involve a comprehensive review of patients prescription and medication data before, during, and after dispensing to ensure appropriate medication decision making and positive patient...