Pharmacogenomic Effect on Biopharmaceutics of Anti-Tubercular Therapy

ISBN-13: 9783330029347 / Angielski / Miękka / 52 str.

Swati Modgil; Shivani Thakur; Rajat Rana

Opis

The first line anti-tuberculosis drugs are known to cause dose related adverse drug reactions like peripheral neuritis and hepatotoxicity. The risk of getting peripheral neuritis have been avoided through a concomitant administration of pyridoxine; while hepatotoxicity remains to be a major adverse effect of anti- tuberculosis therapy. Research findings state reduction in the incidence of hepatotoxicity by exploring a potential link between biopharmaceutical pattern of anti-tuberculosis drugs and genetic polymorphism of the enzymes metabolizing them. Reportedly a significant correlation has been found by pooling the data through a meta-analysis.

O autorze

Modgil, SwatiMs. Swati Modgill is an academician and researcher in the field of development and characterization of biopharmaceuticals. She also prestigious member of various pharmaecutial associations. Ms. Shivani Thakur is a well known scientist and academician with vast research experience over 8 years on Central Nervous system related anomlaies.