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With the most comprehensive and up-to-date overview of structure-based drug discovery and using experimental and computational approaches, this book covers principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development.

- Presents the benefits, limitations, and potentiality of novel techniques in the field, like complex crystallization, X-ray diffraction, NMR, mass spectrometry, and computational chemistry
- Assesses macromolecular structures with experimental, analytical, and therapeutic approaches to reveal a...

Die letzten beiden Wirklichkeiten des Marvel-Multiversums kollidieren mit apokalyptischer Wucht. Und obwohl ihre Helden alles geben, werden ihre Universen ausgelöscht. Was bleibt, ist Battleworld: ein Patchwork-Planet aus den Fragmenten vieler untergegangener Realitäten. Wo Dr. Doom als mächtiger Gottkönig herrscht, Sheriff Strange und die Thors-Polizeitruppe für Ordnung sorgen sollen - und kaum jemand sich erinnert, was einmal gewesen ist. Bis Miles Morales und andere Helden Dooms neue Welt betreten.

project was the development and application of a model of central and local government behavior. It was carried out in collaboration with the Dutch Department of Home Affairs, during the period September 1985 - April 1987. The project's aim was the study of the determinants of local government decisionmaking in the Netherlands and the implications of so-called intergovernmental relations for local government behavior. During that project I was assisted by Sander Helder and Marc Tigche1aar. The results of that project appeared in a book, co-authored by Frans van Winden, entitled...