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Calcium ions are crucial regulators of human physiology and development. This comprehensive guide to the molecular and clinical characteristics of the channels by which they cross membranes covers the diseases affecting them and a range of promising therapies.

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified...

The history of Buczacz is a microcosm of the history of Galician shtetls and yet Buczacz was a more prominent shtetl than many in Galicia. As a spiritual center for Galician Jews, Buczacz produced a number of prominent rabbis, many of whom are named in the Yizkor Book. The town was a center for scholarship as can be seen in the long list of books by Buczacz authors. Buczacz produced prominent internationally known scholars including: Shmuel Yosef Agnon (winner of the Nobel Prize in Literature in 1966); Schlomo Freud (grandfather of Sigmund Freud) and several generations of the Freud...