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The present study deals with the design, development and evaluation of microspheres of an antidiabetic drug by using different polymers for entrapping the drug to give controlled release, minimize frequent dosing thus improving patient compliance. Two different methods were used for preparing the different formulation of microspheres viz. ionotropic gelation method and non-aqueous solvent evaporation method.

During the past two decades, significant advances have been made in the area of controlled release as evidenced by an increasing number of patents, publications, as well as commercial controlled-release products for the delivery of a variety of bioactive agents. Here, an attempt is made to formulate the matrix type transdermal films of quetiapine fumerate, an anti-psychotic drug using various polymers to sustain its action and evaluate the prepared films using various parameters.