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This issue of Hematology/Oncology Clinics of North America, devoted to Colorectal Cancer, is edited by Dr. Leonard B. Saltz. Articles in this issue include: Diet and Lifestyle Influences on Colorectal Cancer; Diagnosis and Management of Germline and Somatic Mutations in Mismatch Repair-deficient Colorectal Cancer; Adjuvant Chemotherapy in Stage II, III, and Resected Stage IV Colon Cancer; Predictive and Prognostic Markers in the Treatment of Colorectal Cancer; Surgical Management of Hepatic Metastases of Colorectal Cancer; Combination Therapies in Colorectal Cancer Treatment; A Critical Look...

Management options for patients with colorectal cancer have undergone d- matic changes over the past decade. Whereas at the start of 1996 only one drug, 5-Fluorouracil, was available for the treatment of this disease, a mere 10 yr later, six drugs are licensed for use in colorectal cancer, and others are in the late phases of clinical development. Likewise, surgical and ablative options, as well as an array of supportive medications, have shown substantial progress and undergone a dramatic proliferation over the past decade. With the increased number of therapeutic options from which to...

The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities. An explosion of understanding in the basic science that underlies both the disease and its potential therapies has translated into remarkable technological advances that can now be applied. So many specialties and subspecialties have now been brought to bear that it is appropriate to attempt to bring the expertise from these areas together in one volume, so that practitioners in one aspect of colorectal cancer management can maintain...

The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities. An explosion of understanding in the basic science that underlies both the disease and its potential therapies has translated into remarkable technological advances that can now be applied. So many specialties and subspecialties have now been brought to bear that it is appropriate to attempt to bring the expertise from these areas together in one volume, so that practitioners in one aspect of colorectal cancer management can maintain...

Recent advances in the understanding of the biology of colorectal cancer have radically transformed the treatment options available to clinicians, leaving textbooks written only two years ago completely out of date. This evidence-based and data-driven guide presents reviews of cutting-edge therapies for colorectal cancer, all articulated by leading experts in the field. This integrated and focused consideration of colorectal management includes reviews of cytotoxic chemotherapy, targeted biologic therapies, as well as updates on adjuvant chemotherapy for colon cancer and combined modality...