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Pain is an unpleasant but very important biological signal for danger. Nociception is necessary for survival and maintaining the integrity of the organism in a potentially hostile environment. Pain is both a sensory experience and a perceptual metaphor for damage and it is activated by noxious stimuli that act on a complex pain sensory apparatus. However, chronic pain having no more a protective role can become a ruining disease itself, termed "neuropathic pain."

This monograph offers a comprehensive review of present knowledge of the structure and connections of the trigeminal nuclei in humans, and compares it to laboratory animal findings. The authors provide cytoarchitectural data from their own research, and trace trigeminal pathways in human material by means of the Nauta technique. In humans the trigeminal nuclear complex includes the motor nucleus, the principal sensory (pontine) nucleus, the spinal nucleus (subdivided into oral, interpolar and caudal nuclei), and the mesencephalic nucleus and several small nuclei. The supratrigeminal nucleus,...