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G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This...

Most existing robust design books address design for static systems, or achieve robust design from experimental data via the Taguchi method. Little work considers model information for robust design particularly for the dynamic system. This book covers robust design for both static and dynamic systems using the nominal model information or the hybrid model/data information, and also integrates design with control under a large operating region. This design can handle strong nonlinearity and more uncertainties from model and parameters.

Genetics of Monogenic and Syndromic Obesity is the latest volume in the Progress in Molecular Biology and Translational Science series.

• Contains contributions from leading authorities
• Informs and updates on all the latest developments in the field

This book describes a complete revolution in software engineering based on complexity science through the establishment of NSE - Nonlinear Software Engineering paradigm which complies with the essential principles of complexity science, including the Nonlinearity principle, the Holism principle, the Complexity Arises From Simple Rules principle, the Initial Condition Sensitivity principle, the Sensitivity to Change principle, the Dynamics principle, the Openness principle, the Self-organization principle, and the Self-adaptation principle. The aims of this book are to offer revolutionary...

This book describes a complete revolution in software engineering based on complexity science through the establishment of NSE Nonlinear Software Engineering paradigm which complies with the essential principles of complexity science, including the Nonlinearity principle, the Holism principle, the Complexity Arises From Simple Rules principle, the Initial Condition Sensitivity principle, the Sensitivity to Change principle, the Dynamics principle, the Openness principle, the Self-organization principle, and the Self-adaptation principle. The aims of this book are to offer revolutionary...

Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

Advances in Pharmacology provides a rich collection of reviews on timely topics. The series places emphasis on the molecular bases of drug action, both applied and experimental.

• Contributions from the best authors in the field
• An essential resource for pharmacologists,...

This book provides a contextualized and balanced look into the timely topic of values in English Language Teaching (ELT) materials with a primary focus on the Chinese context. It features three distinct conceptual and methodological perspectives, namely, perceptions of stakeholders such as material writers, teachers and students, multimodal construction of values, and textual representation of values. It is a valuable resource for those interested in the social, cultural, moral, and ideological dimensions of English education in general, and in the textual and multimodal construction...

• Written by experts in the field
• Informs on important topics related to the regulation of glucose homeostasis and the pathogenesis of diabetes mellitus, a field of intense research interest

Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans.

• Subject matter: obesity is an epidemic and G protein-coupled receptors are promising drug targets, with significant...