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Cancer is a devastating disease and the depth study is also keeping pace with its spread. Signal transduction holds an important key to the origin and propagation of cancers. Among all other protein involved in proliferation of cell, RhoGTPase rac1 is also involved. This book highlights the recent advances made in the field with special emphasis on key regulators of signal transduction. This book also showcases the results of the study taken in looking at the expression pattern of cancers.

EPS8 protein has been known to be involved in the signaling pathway of different cancers, and protein E3B1 is considered to be a downstream target for EPS8. By participating in the formation of various macromolecular complexes, E3B1 has been found to mediate a number of signal pathways related to cancer cell proliferation. We carried out expression analysis studies of EPS8 in esophageal, stomach and lung carcinomas, and observed increased expression of the protein in esophageal and stomach cancers, whereas, the observed expression of this protein in lung cancers was fairly equal. Likewise,...

Understanding the role of SNTA-1 protein in carcinogenesis can be of enormous help in the understanding of carcinogenesis. It may provide evidence for potential, novel, emerging or re-emerging targets for one or more diseases. We studied the expression of 1-syntrophin (SNTA1) protein in histologically confirmed esophageal, stomach, lung, colon, rectal and breast cancerous human tissue samples. Our results suggest a significant decrease in the expression level of SNTA1 protein in both esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) compared with their respective...