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Leishmaniasis is prevalent through out the tropical and sub-tropical regions of Africa, Asia, the Mediterranean, Southern Europe (old world) and South and Central America (new world). It is estimated that approximately 12 million people are currently infected and a further 367 million are at risk of acquiring Leishmaniasis in 88 countries, 72 of which are developing countries and 16 of them are among the least developed in the world. The estimated incidence is 2 million new cases each year of which 0.5 million are of VL and 1.5 million are of CL. Immune system plays an important role in...

An accessible introduction to performing meta-analysis across various areas of research

The practice of meta-analysis allows researchers to obtain findings from various studies and compile them to verify and form one overall conclusion. Statistical Meta-Analysis with Applications presents the necessary statistical methodologies that allow readers to tackle the four main stages of meta-analysis: problem formulation, data collection, data evaluation, and data analysis and interpretation. Combining the authors' expertise on the topic with a wealth of up-to-date information, this book...

An advanced discussion of linear models with mixed or random effects.

In recent years a breakthrough has occurred in our ability to draw inferences from exact and optimum tests of variance component models, generating much research activity that relies on linear models with mixed and random effects. This volume covers the most important research of the past decade as well as the latest developments in hypothesis testing. It compiles all currently available results in the area of exact and optimum tests for variance component models and offers the only comprehensive treatment for...