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Pathological changes in the pulp and periradicular tissues are due to microorganisms and their byproducts. To achieve optimal healing of periradicular tissue and better prognosis of endodontic treatment, complete elimination of microorganisms, their byproducts, and infected tissue is the main goal of endodontic therapy. Mechanical instrumentation, antimicrobial irrigation, and intracanal medicaments are the commonly-employed methods to eliminate intracanal microbial load. However, mechanical instrumentation still remains the mainstay of root canal disinfection, as it provides a platform for...