Wyniki wyszukiwania:

Inexpensive and female - controlled pre - exposure prophylaxis strategies to prevent mucosal transmission of the virus, is urgently needed with the rising prevalence of human immunodeficiency virus (HIV - 1 and HIV-2) infections in women. Zidovudine - loaded vaginal pessaries may become one of the potent weapons, as it can be used not only for controlled release but also for enhancing bioavailability. Drug delivery through vaginal pessary is a promising area for continued research with the aim of achieving controlled release in a slow and sustained manner over longer periods of time. The aim...

The aim of this study was to develop and evaluate Zidovudine (AZT) loaded microparticulated bioadhesive vaginal gel (AZMBVG) in order to obtain a controlled-releasing, in order to obtain a controlled-release system for treatment of AIDS. AZT microparticle AZMCs was prepared by O/O single emulsion solvent evaporation method (II) and evaluated for encapsulation efficiency, drug loading, surface morphology and invitro drug release profiles and drug release mechanism and optimized. To achieve second objective, optimized AZMC4 were encompassed in bioadhesive gel to form AZMBVGs by cold mechanical...