Anti-HIV Bioadhesive Microencapsulated Vaginal Gel

ISBN-13: 9783659149986 / Angielski / Miękka / 2012 / 224 str.

Arkendu Chatterjee; Benoy Brata Bhowmik; K. Gauthaman

Opis

The aim of this study was to develop and evaluate Zidovudine (AZT) loaded microparticulated bioadhesive vaginal gel (AZMBVG) in order to obtain a controlled-releasing, in order to obtain a controlled-release system for treatment of AIDS. AZT microparticle AZMCs was prepared by O/O single emulsion solvent evaporation method (II) and evaluated for encapsulation efficiency, drug loading, surface morphology and invitro drug release profiles and drug release mechanism and optimized. To achieve second objective, optimized AZMC4 were encompassed in bioadhesive gel to form AZMBVGs by cold mechanical method and compared with the bioadhesive vaginal gel (BVG1) without microcapsule. The optimized microcapsules were incorporated in bioadhesive gel prepared using different bioadhesive polymer evaluated the gel for the encapsulation efficiency, drug loading,invitro release profiles and drug release kinetics, spreadability, extrudibility, bioadhesion , vaginal irritancy and pharmacokinetics study by invivo methods by using New Zealand white female rabbit model. A comprehensive protocol, for the AZMBVG was developed successfully. Further research in this area will be significant outcome for AIDS

O autorze

Achievement encompasses major contribution by author during his entire research work. The author has presented his work in different scientific forums at national and international level with three best papers awarded and financial assistance under international travel support scheme by AICTE,DST.Having 13 national and 2 international publication.