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This book has its origin in my experience as a teacher of pharmacokinetics in many universities in four different continents. It was not my intention to write a popular book; what distinguishes this one from many others on the same subject is its large use of algebra and calculus. For this I make no apologies; in fact a serious study of pharmacokinetics without the help of mathematics is, in my opinion, impossible. The exact definition of many pharmacokinetic quantities, even the most common, and the correct use of many equations, even the most simple, requires the constant use of...

This book has its origin in my experience as a teacher of pharmacokinetics in many universities in four different continents. It was not my intention to write a popular book; what distinguishes this one from many others on the same subject is its large use of algebra and calculus. For this I make no apologies; in fact a serious study of pharmacokinetics without the help of mathematics is, in my opinion, impossible. The exact definition of many pharmacokinetic quantities, even the most common, and the correct use of many equations, even the most simple, requires the constant use of...

The last decade or so has witnessed tremendous progress in methodology in the field of drug development in general and pharmacokinetics in particular. Clinical pharmacokinetics is using new tools for probing into the "black box" once being ac cessible only partly through experimental techniques and, mostly through mathemati cal and computer means. Development of computerized scanning, positron emission tomography (PET), stereoselectivity and other techniques are now enabling investi gators to have better pictures of the systems they are studying. Mathematical models through computer...

This volume showcases the most important developments in the area of plasminogen regulation. The book is composed of about 16 chapters dealing with a range of topics including the mechanisms of activation of plasminogen, the structure of plasminogen and plasminogen activators, the role of plasminogen in various physiological and pathological processes (such as tumour growth and progression, wound healing and fibrinolysis) and the interrelationship of the plasmin/MMP proteolytic systems.