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TheobservationthatabloodclotspontaneouslydissolveswasfirstdescribedbyDenys in1889. Subsequently, thebloodclottingsystemwasshowntobeinvolvedintumor growth. Forexample, asearlyas1925, Fisherreportedthataviantissueexplantstrans- formedtomalignancybyvirusesgeneratedhighlevelsoffibrinolyticactivityundercon- ditionsinwhichculturesofnormalcellsdidnot. In1958, theconceptthatan equilibriumexistedbetweenthetendencyofbloodtoclotandtoremainfluidwaspro- posedbyAstrup. Atthattime, itwasbelievedthatthishemostaticbalancewasexplained...

Fibrinolysis, the process of breaking down the fibrin network, was reported in 1925 by Fischer, who demonstrated that explants of virally induced chicken tumors rapidly caused lysis of plasma clots, whereas explants of normal tissue did not. This observation provided evidence for the importance of fibrinolysis in cancer. Then, in 1933, Tillett and Garner observed the liquefaction of a fibrin clot by the plasma of many patients who had recovered from acute hemolytic streptococcal infections. These investigators showed that broth cultures of hemolytic streptococci derived from patients could...

This volume showcases the most important developments in the area of plasminogen regulation. The book is composed of about 16 chapters dealing with a range of topics including the mechanisms of activation of plasminogen, the structure of plasminogen and plasminogen activators, the role of plasminogen in various physiological and pathological processes (such as tumour growth and progression, wound healing and fibrinolysis) and the interrelationship of the plasmin/MMP proteolytic systems.