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TheobservationthatabloodclotspontaneouslydissolveswasfirstdescribedbyDenys in1889. Subsequently, thebloodclottingsystemwasshowntobeinvolvedintumor growth. Forexample, asearlyas1925, Fisherreportedthataviantissueexplantstrans- formedtomalignancybyvirusesgeneratedhighlevelsoffibrinolyticactivityundercon- ditionsinwhichculturesofnormalcellsdidnot. In1958, theconceptthatan equilibriumexistedbetweenthetendencyofbloodtoclotandtoremainfluidwaspro- posedbyAstrup. Atthattime, itwasbelievedthatthishemostaticbalancewasexplained...

This volume showcases the most important developments in the area of plasminogen regulation. The book is composed of about 16 chapters dealing with a range of topics including the mechanisms of activation of plasminogen, the structure of plasminogen and plasminogen activators, the role of plasminogen in various physiological and pathological processes (such as tumour growth and progression, wound healing and fibrinolysis) and the interrelationship of the plasmin/MMP proteolytic systems.