The Exposome: A Primer

ISBN-13: 9780124172173 / Angielski / Miękka / 2013 / 118 str.

Miller, Gary W.

Opis

The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

Recenzje

"There is some suggestions for teaching the exposome, including an outline syllabus for a short course, and Miller's ideas about how the science might move forward over the next five to ten years. Overall I found this a useful introduction to the exposome and well worth reading if you want to better understand this new developing science." --OH-World.org blog, January 2014

Spis treści

1. The exposome: purpose, definition, and scope2. When the genome falls short: limitations of a gene-centric view of health3. Omic-based technologies and their impact on the exposome4. The exposome in environmental health sciences and related disciplines5. Managing and integrating exposome data: maps, models, computation, and systems biology6. An exposome education: university and community-the practical exposome7. Staging the exposome: a vision for international collaboration

O autorze

Gary W. Miller, PhD is the Vice Dean for Research Strategy and Innovation and Professor of Environmental Health Sciences at the Mailman School of Public Health at Columbia University. He was founding director of the HERCULES Exposome Research Center at Emory University, the first exposome-based center in the U.S. In addition to his work on the exposome, his research interests include the role of environmental factors in neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, and the regulation of dopamine signaling in the brain. He served as Editor-in-Chief of Toxicological Sciences, the official journal of the Society of Toxicology, from 2013-2019.