Single Cell Sequencing and Systems Immunology

ISBN-13: 9789401797528 / Angielski / Twarda / 2015 / 177 str.

Xiangdong Wang

Opis

The volume will specially focus on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding molecular mechanisms of systems immunology. The present volume will provide readers revealing insights into and share personal experience on the potential application, significance, workflow, comparison, perspective in future, and challenges of single cell sequencing for discovery and development of disease-specific biomarkers, to understand biological function, activation, or dysfunction of single cells or lymphocytes, to explore functional roles and responses of single cells to therapies. It will provide revealing in-depth information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor-function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics science, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, role in the diseases, and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

Spis treści

Preface.- Significance of Single Cell Sequencing in Future Medicine.- Uncovering Phenotypes with Supercells: Applications to Single-Cell Sequencing.- Single-Cell Sequencing of Microorganisms.- Application of single-cell sequencing in dynamic transcriptomes.- System Immunology in Metabolic Research of Dendritic Cells.- FOXP3+ Treg Cells and Systems Biology Approaches to Studying Their Function.- γδT Cells and αβT Cells.- Prolymphocyte: Lymphocytes and Bioinformatics.- Lymphocytes in liver cancer.- Early biomarkers of hepatocyte necrosis.- Protocol of Single Cell Isolation by Flow Cytometry.- Single-cell based omics-the new era of human disease and medicine.- Cancer bioinformatics.         

Blurb

The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects.

 

Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.