Separation Techniques in Clinical Chemistry

ISBN-13: 9780824740139 / Angielski / Twarda / 2003 / 552 str.

Hassan Y. Aboul-Enein; Aboul-Enein Y. Aboul-Enein; Hassan Y. Aboul-Enein

Opis

This reference examines innovations in separation science for improved sensitivity and cost-efficiency, increased speed, higher sample throughput and lower solvent consumption in the assessment, evaluation, and validation of emerging drug compounds. It investigates breakthroughs in sample pretreatment, HPLC, mass spectrometry, capillary electrophoresis and therapeutic drug monitoring for improved productivity, precision, and safety in clinical chemistry, biomedical analysis, and forensic research.

Spis treści

Sample pretreatment in clinical chemistry, I.N. Papadonoyannis and V.F. Samanidou; the separation science in therapeutic drug monitoring, Zak K. Shihabi; the impact of chirality in pharmacokinetics and therapeutic drug monitoring, Karla A. Moore and Barry Levine; HPLC in bioavailability examination, Zdzislaw Chilmonczyk, Kamila Kobyliska, and Hassan Y. Aboul-Enein; validation of HPLC analyses in therapeutic drug monitoring, Zdzislaw Chilmonczyk, Iwona Cendrowsk and Hassan Y. Aboul-Enein; analysis of illicit drugs with chromatography, M.J. Bogusz; biogenic amine neurotransmitters - their importance and measurement in human tissue and body fluids, Adarsh M. Kumar; clinical applications of affinity chromatography, William Clarke and David S. Hage; immunoaffinity chromatography in clinical analysis, David S. Hage and William Clarke; electrospray tandem mass spectrometry in biochemical genetics laboratory, Mohamed S. Rashed; application of thin-layer chromatography, Jan Bladek and Slawomir Neffe; applications of capillary electrophoresis in clinical analysis of drugs, Jacek Bojarski and Joanna Szymura-Oleksiak.

O autorze

Hassan Y. Aboul-Enein is Principal Scientist, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. Professor Aboul-Enein is the author, coauthor, editor, or coeditor of nearly 500 journal articles, book chapters, and books including Analytical and Preparative Separation Methods of Biomacromolecules and Electrochemical Sensors in Bioanalysis (both titles, Marcel Dekker, inc.). He is a member of the editorial boards of several journals, including the Journal of Liquid Chromatography & Related Technologies and Analytical Letters (both journals, Marcel Dekker, inc.). He is a member of the World Health Organization's advisory panel on international pharmacopeia and pharmaceutical preparations and a Fellow of the Royal Society of Chemistry (UK). Professor Aboul-Enein received the B.Sc. degree (1964) in pharmacy and pharmaceutical chemistry from Cairo University, Egypt, and the M.Sc. (1969) and Ph.D. (1971) degrees in pharmaceutical and medicinal chemistry from the University of Mississippi.