This volume discusses the impact of chirality and stereochemistry on drug development and use, including analytical, pharmacological and regulatory topics. It is wide-ranging and includes stereoisomeism in drug development.

Reports up-to-date research developments on purifying and isolation large organic molecules. The text provides information on high-performance liquid chromatography and capillary electrophoresis (CE) as tools for analyzing biomacromolecules and developing new biochemical and medicinal compounds. It applies biochemical separation technology to the study of macromolecules such as proteins, polysaccharides, nucleic acids and more.

This reference examines innovations in separation science for improved sensitivity and cost-efficiency, increased speed, higher sample throughput and lower solvent consumption in the assessment, evaluation, and validation of emerging drug compounds. It investigates breakthroughs in sample pretreatment, HPLC, mass spectrometry, capillary electrophoresis and therapeutic drug monitoring for improved productivity, precision, and safety in clinical chemistry, biomedical analysis, and forensic research.

Quality and reliability are central to success in every discipline, but perhaps nowhere are they more important or more interconnected than in the practice of analytical chemistry. Here, although reliable analytical information implies quality, not all quality information proves reliable.Quality and Reliability in Analytical Chemistry examines the various factors affecting these parameters in each step of the analytical process: The Sample: Investigate the reliability of the sample, including its history and homogeneity.The Method: See the connection between reliability and the selection of...

The knowledge of metal ion speciation is essential for predicting the exact toxicities of metal ion species in the environment. Metal ions can exist in various oxidation states, each of which possesses different physical and chemical properties as well as exhibit varying toxicities. Often, toxicity data is unreliable because it is based on metal ion concentration measurements that fail to identify a dominant species either more or less harmful than the average. Instrumental Methods in Metal Ion Speciation provides analytical techniques and experimental methodologies for determining the...