Protein Structure Prediction: A Practical Approach

ISBN-13: 9780199634965 / Angielski / Miękka / 1997 / 320 str.

M. Sternberg

Opis

The prediction of the three-dimensional structure of a protein from it s amino acid sequence is a problem faced by an increasing number of bi ological scientists. This book provides a practical guide to making th ese predictions by reviewing strategies of different computer modeling algorithms and highlighting the degree of confidence attributed to th em. Also in the volume are descriptions of the following: the principl es of protein folding; sequence homology and motif searches; predictio n of secondary structure; homology modeling; modeling of antibody comb ining sites; tertiary fold recognition; modeling of transmembrane prot eins; ab initio prediction; protein-ligand docking simulations; and th e use of molecular mechanics and dynamics. both non-specialists who re quire guidance to identify and evaluate appropriate strategies and exp erts who require a contemporary view of the field, will find this volu me a worthy addition to their research libraries.

Recenzje

wide ranging and very well documented accounts of the many practical aspects and various areas of application. The book should be of practical value especially to geneticists and molecular biologists.