Protein Modificomics: From Modifications to Clinical Perspectives

ISBN-13: 9780128119136 / Angielski / Miękka / 2019 / 387 str.

Tanveer Ali Dar; Laishram Rajendrakumar Singh; Parvaiz Ahmad

Opis

Protein Modificomics: From Modification to Clinical Applications comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins including diseases involving PTM's, plant PTM's, role of therapeutic strategies and other topics such as translational proteomics. PTMs make the major backbone of several key biological processes. It has been known that many proteins often undergo unwanted modifications leading to the disruption of proteostasis and ultimately gain in disease etiology. These diseases include Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome, OFC10 etc. Cancer is also one of the major complex diseases wherein various proteins undergo undesired modifications that result in deregulation of the cell cycle, disruption of DNA repair mechanisms and also the inactivation of the proapoptotic pathways etc. Furthermore, the allosteric insight to regulation or deregulation of the protein structure due to modifications is of immense importance for designing drugs for therapeutic intervention of diseases caused due to the modifications. PTMs also play a very important role in plant physiology and production of medicinally important primary and secondary metabolites. Understanding of PTMs in plants will help us to enhance the production of these metabolites without greatly altering the genome. This will give us robust eukaryotic systems for production and isolation of desired products without considerable downstream and isolation processes.

• Collects in one place a thorough insight into post translational modifications (PTMs) of proteins in both the plant and animal kingdom along with current techniques involved with studying PTMs
• Diagrammatic representation of various protein modification and estimation mechanisms in four-color
• Includes coverage of diseases involving post translational modifications

Spis treści

1. Emerging roles of posttranslational modifications in biological processes and their implications in associated diseases 2. Clinical perspective of posttranslational modifications 3. Phosphorylation and acetylation of proteins as posttranslational modification: implications in human health and associated diseases 4. Protein modifications and lifestyle disorders 5. Ubiquitin mediated posttranslational modification of proteins involved in various signaling diseases 6. Improving pharmacological efficacy of protein pharmaceuticals by glycosylation 7. Posttranslational modification in human therapeutics heterologously produced in plant host expression systems 8. Protein modification in plants in response to abiotic stress 9. Posttranslational modifications associated with cancer and their therapeutic implications 10. Nonenzymatic posttranslational protein modifications: mechanisms and associated disease pathologies 11. Protein covalent modification by homocysteine: consequences and clinical implications 12. Posttranslational modifications in algae: role in stress response and biopharmaceutical production 13. Protein glycosylation: an important tool in diagnosis or early detection of diseases

O autorze

Dr. Dar received his Master's in Biochemistry for Hamdard University, New Delhi, India in 2003 and PhD in Biosciences from Jamia Millia Islamia, New Delhi in 2009. After completing his doctorate, he joined as post-doctorate in Prof. Bruce Bowler's lab at the University of Montana, Missoula, USA. He is currently an Associate Professor at the Department of Clinical Biochemistry, University of Kashmir, India. His research focus mainly includes modulation of aggregation of globular as well as Intrinsically disordered proteins by chemical chaperones/osmolytes and the structural-functional characterization of biologically active proteins from medicinal plants. He has authored more than 50 publications in both national and international journals of repute in the field of protein biophysics and medicinal plant proteomics. He has also edited four books. Dr. Laishram Rajendrakumar Singh is a Professor at the University of Delhi, India. He obtained his PhD in protein biophysics from Jamia Millia Islamia, New Delhi, and following this continued his postdoctoral research at Fox Chase cancer Center, Philadelphia (FCCC), USA. During his doctoral study he was engaged in investigating how small molecule compounds affect native protein structure, stability and enzymatic catalysis. At FCCC his main research interest encompasses understanding the proteiostasis and modulators toward the functional restoration of disease-causing pathogenic protein variants. Currently Dr. Singh is working on understanding the molecular insights of proteopathy and developing small molecule compounds for various toxic protein inclusions associated with neurodegenerative diseases. He has more than 75 publications to his credit in various international journals of repute. He is also guest editor and editorial member of various international journals.