Pathogenicity of Human Herpesviruses Due to Specific Pathogenicity Genes

ISBN-13: 9783642850066 / Angielski / Miękka / 2011 / 387 str.

Yechiel Becker; Gholamreza Darai

Opis

The questions of how the pathogenic human herpesviruses cause diseases, and what should be done to prevent infection and disease have prompted scientific interest in the molecular basis of the functions of all human herpesvirus genes in various tissues and organs of the infected host. This volume compiles the knowledge on the pathogenicity genes of herpes simplex virus types 1 and 2, the ones which have been most actively investigated at the molecular level. It adds to the understanding of herpesvirus gene involvement in diseases and shows the potential of this knowledge for planning new strategies for the development of vaccines in the future. The book will be of great help to physicians and to scientists concerned with the involvement of herpesviruses in aggravating patients' conditions, leading to a life threatening infection.

Spis treści

A. Herpes Simplex Virus.- I. Genes Involved in Entry.- 1 Entry of Herpes Simplex Virus Type 1 into Cells — Early Steps in Virus Pathogenicity.- 2 Neomycin and Herpes Simplex Virus Receptor Binding: The Role of Glycoprotein C.- 3 Pathogenicity of Glycoprotein C-Negative Herpes Simplex Virus Type 1 in Herpetic Keratitis.- 4 Structure and Function of Glycoprotein D of Herpes Simplex Virus.- II. Genes Coding for Enzymes.- 5 The Role of Herpes Simplex Virus Thymidine Kinase Expression in Pathogenesis and Latency.- 6 Herpes Simplex Virus Type 1 DNA Polymerase: Eukaryotic Model Enzyme and Principal Target of Antiviral Therapy.- 7 Ribonucleotide Reductase and the Ocular Virulence of Herpes Simplex Virus Type 1.- 8 Ribonucleotide Reductase Gene in Herpes Simplex Virus Type 2 and Virus Pathogenicity.- III. Genes Related to Intraperitoneal Pathogenicity.- 9 Effect of Herpes Simplex Virus Type 1 UL41 Gene Product on mdr-1 Gene-mRNA in Infected Adrenal Glands.- 10 Pathogenicity and Latency of Herpes Simplex Virus in the Animal Model System Tree Shrew.- 11 Computer Analysis of the Protein Coded by Herpes Simplex Virus Type 1 UL56 Gene.- IV. Genes and Latency and Intracerebral Pathogenicity.- 12 The Herpes Simplex Type 1 Virus Latency Gene.- 13 Neurovirulence of Herpes Simplex Virus Type 1 Accessory Gene Mutants.- 14 Herpes Simplex Virus Latency and Immediate Early Gene Repression by the Cellular Octamer-Binding Protein Oct-2.- 15 The Cell Fusion Protein Gene (UL53) of Herpes Simplex Virus Type 1—A Pathogenicity Gene.- V. Effect of Cellular Defenses on Virus Pathogenicity.- 16 Role of Langerhans Cells and Other Dendritic Cells in the Pathogenesis of Herpes Simplex Virus Type 1 Infection.- B. Epstein Barr Virus.- 17 Gene Expression in Burkitt’s Lymphoma Cells.- 18 Molecular Mechanisms of the Development of EBV-Related B Lymphomas: Functional Cooperation of EBV with IL-6 and HIV-1.- C. Human Cytomegalovirus.- 19 Murine Cytomegalovirus Genes Influencing Virus Growth and Tropism for Salivary Gland.- D. Human Herpesvirus 6.- 20 Pathogenicity of Human Herpesvirus-6.- E. Trends.- 21 Herpes Simplex Virus Type 1 Genes Involved in Virus Pathogenicity: A Review.- 22 Live Herpesvirus Vaccines: Serendipity or Engineering of the Virus Genome.