Omega-3 fatty acids attenuate DNA damage in experimental diabetes

ISBN-13: 9783659664762 / Angielski / Miękka / 2014 / 148 str.

Hussein Jihan;Taha Mamdouh;Mohamed Sahar

Opis

Supplementation of omega-3 fatty acids is very effective in reducing oxidative stress through the improvement of antioxidant enzymes activities . Fish and flaxseed oils are nutritional supplements have a high concentration of omega-3 fatty acids.Flax seed oil is rich in alpha linolenic acid (ALA) while fish oil is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this study we aimed to compare the effects of flaxseed and fish oils in reducing oxidative stress especially in attenuating DNA damage through the evaluation of urinary 8-hydroxyguanosine (8-OHdG) in experimental diabetes. The main finding in our study was the reduction of urinary isoprostanes and 8-OHdH , in addition to the reduction of insulin resistance during diabetes. In conclusion, flaxseed and fish oils administration has a potential effect on decreasing insulin resistance in diabetic rats through the scavenging of free radicals and increasing superoxide dismutase . This study also concluded that ,fish oil was more effective than flaxseed oil.

O autorze

Prof.Jihan Seid Hussein,Professor of Medical Biochemistry, National Research Centre,Egypt.Member of several international scientific societies ,awarded a scientific encouragement prize in Biotechnology of the National Research Centre in 2011. Holds a Scientific Excellence Award for the research outputs for the years 2009, 2010, 2011,2012 and 2013.