Diabetes mellitus is a complex metabolic disease associated with peripheral and central complications. These complications include retinopathy, nephropathy and neuropathy. Several investigations have confirmed the role of oxidative stress in developmental diabetic mediated disorders, possibly via the formation of free radicals . Chronic antioxidant therapies may be useful in decreasing the risk of diabetic complications, from these antioxidants coenzyme Q10 which acts as an antioxidant, inhibiting lipid peroxidation and scavenging free radicals. This study aimed to investigate the brain...

Hyperglycemia results in excessive production of free radicals which leads to sever oxidative damage of the cell components like lipids, proteins and DNA. These radicals attack the polyunsaturated fatty acids in the cell membrane leading to disturbances in membrane structure and properties such as membrane permeability, integrity and also the binding of insulin to its receptors that is embedded in the cell membrane, Thus it was found that membrane enriched in unsaturated fatty acids tends to bind more insulin than membrane enriched in saturated fatty acids, and the membrane components may be...

Supplementation of omega-3 fatty acids is very effective in reducing oxidative stress through the improvement of antioxidant enzymes activities . Fish and flaxseed oils are nutritional supplements have a high concentration of omega-3 fatty acids.Flax seed oil is rich in alpha linolenic acid (ALA) while fish oil is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this study we aimed to compare the effects of flaxseed and fish oils in reducing oxidative stress especially in attenuating DNA damage through the evaluation of urinary 8-hydroxyguanosine (8-OHdG) in experimental...

Diabetes mellitus and hypertension represent major causes of chronic kidney diseases and initiation of dialysis; In addition, glomerular diseases, malnutrition, infectious diseases, and acute kidney injury can progress to end-stage renal disease, contributing to the increased global burden of death associated with this condition. Current treatment modalities often fail to target the major underlying contributors for progression of renal disease. Indications for kidney transplantation have expanded considerably in terms of recipient age, primary disease leading to end-stage renal failure, and...

Gastric ulcer disease is the most common ulcer of the gastrointestinal tract. It is caused by many factors such as drugs, stress or alcohol. Several factors are implicated in the pathogenesis of gastric ulcer. These include increased acid-pepsin secretion, impaired bicarbonate neutralization, impaired mucus secretion and precipitate lesions on the mucosal layer. A number of drugs including prostaglandins analogs, histamine receptor antagonists, proton pump inhibitors, and cytoprotective agents are available for the treatment of gastric ulcer. By the way various side effects of these products...