Nucleic Acids and Molecular Biology

ISBN-13: 9783642786686 / Angielski / Miękka / 2012 / 330 str.

Fritz Eckstein;David M. J. Lilley

Opis

Molecular biology is one of the most rapidly developing and at the same time most exciting disciplines. The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins.
Nucleic Acids and Molecular Biology keeps scientists informed of the explosively growing information and complies with the great interest in this field by offering a continued high standard of review. A substantial part of this volume has been devoted to the analysis of different aspects of nucleic acid-protein-interactions including RNA-protein-interaction.

Spis treści

Probing of DNA Structure with Osmium Tetroxide Complexes in vitro and in Cells.- Structural Engineering of Nucleic Acids by Disulfide Cross-Linking.- Cryo-Electron Microscopy of DNA.- The Hairpin Elements of Nucleic Acid Structure: DNA and RNA Folding.- The Hairpin Ribozyme.- Conformation and Energetic of Supercoiled DNA: Experimental and Theoretical Studies.- Supercoiling Induced by Transcription.- Topological Coupling Between Promoters.- Bleomycin-DNA Interactions.- Adaptability and Specificity in DNA Binding by trp Repressor.- The ? Sliding Clamp of E. coli Polymerase III Balances Opposing Functions.- Structure and Function of T4 Endonuclease V.- Structure and Function of the DNA Repair Enzyme Endonuclease III.- Resolvase-Mediated Site-Specific Recombination.- Mechanism of Site-Specific Recombination: The FLP Paradigm.- Achilles’ Cleavage: Conferring the Specificities of DNA-Binding Molecules on Restriction Endonucleases.- Oligonucleotide Based Therapeutics of Human Malignancies.