Nigella sativa Linn. ameliorates D-galactosamine/LPS induced hepatitis

ISBN-13: 9783659707810 / Angielski / Miękka / 2015 / 108 str.

Jaswal Amita;Shukla Sangeeta;Raghuvanshi Suchita

Opis

D-Galactosamine (D-GaIN) has been shown to produce a liver damage closely related to human viral hepatitis with necrosis, inflammation and regeneration. Hepatotoxicity is one of the common diseased conditions leading to serious consequences ranging from metabolic disorders to even death. Management of liver diseases is still a great challenge to the modern medicine. At present only a few hepatoprotective drugs from natural sources are available and there is lack of effective allopathic medication available for treatment of liver disorders. We evaluated therapeutic potential of ethanolic extract of Nigella sativa (NS) seeds against D-GaIN and LPS induced liver damage in rats. NS is a small herb of the family Ranunculaceae, which has significant traditional usage as medicine and is also known to biosynthesize phytochemicals such as thymoquinone, theymohydroquinone, nigellicimine, terpineol and nigellidine. They have been shown to possess an anti-inflammatory and antioxidant activities.

O autorze

Prof. Sangeeta Shukla, D.Sc.,Ph.D.,M.Sc.,(Gold Medal in Life Sciences) is Vice Chancellor in Jiwaji University, Gwalior (M.P.) India. She has published more than 90 research papers. Dr. Amita Jaswal is working as Research Scholar. Dr. Suchita Raghuvanshi is working as Research Associate in ICMR funded project from the same University.