New Avenues to Efficient Chemical Synthesis: Emerging Technologies

ISBN-13: 9783540708483 / Angielski / Twarda / 2007 / 241 str.

Peter H. Seeberger

Opis

In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged: Microreactor chemistry; Nanotechnology and catalysis research; Microwave-assisted organic synthesis; New developments in solid supported synthesis. This book covers lectures about the theory, use, scope and limitations of these new technologies in chemical synthesis. It provides a useful overview for scientists in the pharmaceutical industry as well as in academic institutions interested in chemical synthesis for drug discovery and development.

Recenzje

From the reviews:

"This book presents the lectures given at the Ernst Schering Foundation Workshop on the titled subject held in Berlin in August/September, 2006. Some of the new technologies in chemical synthesis that are discussed here include microreactor chemistry, nanotechnology and catalysis research, microwave-assisted organic synthesis, and new developments in solid supported synthesis. The book was designed to appeal to scientists in the pharmaceutical industry and academics interested in chemical synthesis for drug discovery and development." (Journal of the American Chemical Society, Vol. 130 (3), 2008)

Spis treści

Microreactors as Tools in the Hands of Synthetic Chemists.- Micro-Fluidic and Lab-on-a-Chip Technology.- Microreactors as New Tools for Drug Discovery and Development.- Microchemical Systems for Discovery and Development.- Isoindolones and Related N-Heterocycles Isoindolones and Related N-Heterocycles via Palladium Nanoparticle-Catalyzed 3-Component Cascade Reactions.- Applying Homogeneous Catalysis for the Synthesis of Pharmaceuticals.- An Integrated Approach to Developing Chemoenzymatic Processes at the Industrial Scale.- Scale-Up in Microwave-Accelerated Organic Synthesis.- Solid Supported Reagents in Multi-Step Flow Synthesis.- Solid-Phase Supported Synthesis: A Possibility for Rapid Scale-Up of Chemical Reactions.- Microstructured Reactors for Development and Production in Pharmaceutical and Fine Chemistry.