Molecular System Bioenergetics: Energy for Life

ISBN-13: 9783527317875 / Angielski / Twarda / 2007 / 633 str.

Valdur Saks

Opis

Every organism must consume energy to survive. The food we eat is ultimately converted into chemical fuel for our cells, and the availability (or non-availability) of these fuels determines whether cells may grow and divide or starve and die. Not surprisingly, the energy metabolism is a key factor in sustaining or blocking the unlimited growth of cancer cells.
In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic.
Following an introduction, they go on to discuss the basic principles, organization and dynamics of cellular energetics, as well as energy transfer networks, metabolic feedback regulation and modeling, finishing off with a section on applied molecular system bioenergetics.
With its combination of systems biology and cellular energetics, this is an invaluable reference for biochemists, biophysicists, cell and molecular biologists, as well as bioengineers.

Spis treści

Introduction
MOLECULAR SYSTEM BIOENERGETICS: BASIC PRINCIPLES, ORGANISATION AND DYNAMICS OF CELLULAR ENERGETICS
Cellular Energy Metabolism and Integrated Oxidative Phosphorylation
Organization and Regulation of Mitochondrial Oxidative Phosphorylation
Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation and Metabolic Channeling
On the Network Properties of Mitochondria
Structural Organization and Dynamics of Mitochondria in the Cells In Vivo
ENERGY TRANSFER NETWORKS, METABOLIC FEEDBACK REGULATION AND MODELING OF CELLULAR ENERGETICS
Mitochondrial VDAC and its Complexes
Phospho–Creatine Circuit:
Integration of Adenylate Kinase, Glycolytic and Glycogenolytic Circuits in Cellular Energetics
Signaling by AMP–Activated Protein Kinase
Developmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase Deficient Mice
System Analysis of Cardiac Energetics –
Excitation–Contraction Coupling
Principles of Mathematical Modeling and In Silico Studies of Integrated Systems of Cellular Energetics
Modeling Energetics of Ion Transport, Membrane Sensing and System Biology of the Heart
APPLIED MOLECULAR SYSTEM BIOENERGETICS
Mitochondrial Adaptation to Exercise and Training –
A Physiological Approach
Mitochondrial Medicine: The Central Role of Cellular Energetic Depression and Mitochondria in Cell Pathophysiology
Tumour Cell Energetic Metabolome
AMPK and the Metabolic Syndrome
A Systems Biology Perspective of Obesity and Type 2 Diabetes

O autorze

Valdur Saks is Professor of Bioenergetics and Biochemistry at the University of Grenoble, France, and Head of the Laboratory of Bioenergetics at the National Institute of Chemical and Biological Physics in Tallinn, Estonia. A graduate of Moscow University, he was the long–time head of the Laboratory of Cardiac Bioenergetics in Moscow, Russia, before taking up his present positions. Professor Saks has authored over 220 scientific publications and has received numerous scientific awards, including the USSR State Prize in Science and the Internatinoal "Research and Development" Award sponsored by the U.N. and UNICEF. He is a member of the International Society for Heart Research and of the American Physiological and Biophysical Societies.