Molecular Mechanisms of Signalling and Membrane Transport

ISBN-13: 9783642645594 / Angielski / Miękka / 2011 / 335 str.

Karel W. A. Wirtz

Opis

This volume provides a compilation of the main principles of signal transduction mechanisms. The reader will become familiar with the most recent developments on:
- the structure and function of heterotrimeric G-proteins and their receptors;
- the small GTPases Ras, Rho, Rab and Arf;
- EGF receptor, Ca2+ and protein kinase C;
- phosphoinositide kinases (PI-3 kinases);
- phospholipases C and D;
- ceramides and possible modulators of apoptosis;
- transcription factors and gene activation;
- multidrug resistance transporters.

Spis treści

Heterotrimeric and Small G-Proteins.- Heterotrimeric guanine nucleotide binding proteins: structure and function.- G-Protein coupled receptors: structure, functions and mutations.- Heterologous expression of G protein-coupled receptors in yeasts: an approach to facilitate drug discovery.- The role of small GTPases in signal transduction.- Small GTPases in the morphogenesis of yeast and plant cells.- A role for G-protein ??-subunits in the secretory mechanism of rat peritoneal mast cells.- Subcellular localisation of ARF 1-regulated phospholipase D in HL60 cells.- Intra-and Intercellular Communication.- Electrophysiological aspects of growth factor signaling in NRK fibroblasts: the role of intercellular communication, membrane potential and calcium.- Cross-talk between calmodulin and protein kinase C.- Endocytosis and Vesicle Flow.- A function for Eps15 in EGF-receptor endocytosis?.- Proteins, sorted. The secretory pathway from the endoplasmic reticulum to the Golgi, and beyond.- Lipids and Intracellular Signalling.- The roles of PI3Ks in cellular regulation.- Phosphatidylinositol transfer protein, phosphoinositides and cell function.- Receptor regulation of phospholipases C and D.- Ceramide: a central regulator of the cellular response to injury and stress.- Ceramide changes during FAS (CD95/APO-1) mediated programmed cell death are blocked with the ICE protease inhibitor zVAD.FMK. Evidence against an upstream role for ceramide in apoptosis.- The structure, biosynthesis and function of GPI membrane anchors.- Enzyme assisted synthetic approaches to the inositol phospholipid pathway.- Regulation of Nuclear Transcription.- Coupling signal transduction to transcription: the nuclear response to cAMP.- Vitamin E and the metabolic antioxidant network.- Membrane Transport Proteins.- The molecular basis for pleiotropic drug resistance in the yeast Saccharomyces cerevisiae: regulation of expression, intracellular trafficking and proteolytic turnover of ATP binding cassette (ABC) multidrug resistance transporters.- Regulation of carbon metabolism in bacteria.