Providing a survey on current research in eukaryotic signal transduction, some of the topics covered are, the biochemistry and biophysics of cell surface receptors, G-protein mediated signalling pathways, regulation of cyclic AMP, Ca2+, inositol phosphate pathways, the structure and regulation of receptors which are tyrosine protein kinases, and cellular responses to integrated signals.

A NATO Advanced Study Institute on "Molecular Mechanisms of Transcellular Signaling: from the Membrane to the Gene" was held on the Island of Spetsai, Greece, from August 15- 27, 1994. The aim of this Institute was to bring together researchers in the field of signal transduction mechanisms, transcription factors and gene regulation with those actively involved in studies on the implications of oxygen radicals and antioxidant defence mechanisms for cell function. As diverse as these fields may be, the emergence of their interconnection during the course of the Institute was an eye-opener for...

This volume provides a compilation of the main principles of signal transduction mechanisms. The reader will become familiar with the most recent developments on:
- the structure and function of heterotrimeric G-proteins and their receptors;
- the small GTPases Ras, Rho, Rab and Arf;
- EGF receptor, Ca2+ and protein kinase C;
- phosphoinositide kinases (PI-3 kinases);
- phospholipases C and D;
- ceramides and possible modulators of apoptosis;
- transcription factors and gene activation;
- multidrug resistance transporters.