Molecular Dissection of Complex Traits

ISBN-13: 9780849376863 / Angielski / Twarda / 1997 / 336 str.

Andrew H. Paterson

Opis

In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in this field within the context of their historical origins. Leading authorities address central themes in analysis of complex phenotypes, and case histories of important work in this burgeoning field are presented by the principal investigators.
The book is divided into three sections:

Spis treści

Introduction
Of Blending, Beans, and Bristles: The Foundations of QTL Mapping, A.H. Paterson
Fundamental Principles
Molecular Tools for the Study of Complex Traits, M.D. Burow and T.K. Blake
Experimental Design Considerations in Analysis of Complex Traits, G.A. Churchill and R.W. Doerge
Computational Tools for Study of Complex Traits, B.-H. Liu
QTL Mapping in Outbred Pedigrees, C.G. Williams
Mapping QTLs in Autopolyploids, S.-C. Liu, Y.-R. Lin, J.E. Irvine, and A.H. Paterson
QTL Analysis under Linkage Equilibrium, J.F. Taylor and J.L. Rocha
Molecular Analysis of Epistasis, Z. Li
QTL Mapping in DNA Marker-Assisted Plant and Animal Improvement, A.H. Paterson
QTL Analyses: Power, Precision, and Accuracy, W.D. Beavis
High-Resolution Mapping of QTLs, A.H. Paterson
Compilation and Distribution of Data on Complex Traits, D.W. Bigwood
Case Histories
Case History in Plant Domestication: Sorghum, An Example of Cereal Evolution, A.H. Paterson, K.F. Schertz, Y. Lin , and Z. Li
Case History in Crop Improvement: Yield Heterosis in Maize, C.W. Stuber
Case History in Germplasm Introgression: Tomato Genetics and Breeding Using Nearly Isogenic Introgression Lines Derived from Wild Species, D. Zamir and Y. Eshed
Case History in Genetics of Long-Lived Plants: Molecular Approaches to Domestication of a Fast-Growing Forest Tree: Populus, T. Bradshaw
Case History in Animal Improvement: Mapping Complex Traits in Ruminants, M. Georges
Case History in Animal Improvement: Genetic Mapping of QTLs for Growth and Fatness in the Pig, L. Andersson et al.
Case History in Humans: Mapping QTLs for Complex Traits in Humans, H. Sakul and L.R. Cardon
Social Impact of QTL Mapping
From Malthus to Mapping: Prospects for an Impact of Genome Analysis on the World Food Supply, J. Xiao and S.R. McCouch
Ethical Consequences of Mapping QTLs for Complex Human Traits, J.C. Crabbe and J.K. Belknap
Epilogue
Prospects for Cloning the Genetic Determinants of QTLs, A.H. Paterson
Index

O autorze

Andrew H. Paterson