Metal Complex - DNA Interactions

ISBN-13: 9781405176293 / Angielski / Twarda / 2009 / 544 str.

Nick D. Hadjiliadis; Nick Hadjiliadis; Einar Sletten

Opis

Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine. Metal Complex - DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:

• Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal binding to DNA and thermodynamic models.
• Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.
• DNA-Recognition - Nucleases and Sensor describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.
• Toxicological Aspects: deals with structural studies of mercury-DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity.

This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.

Recenzje

"An impressive overview of the great diversity of current research." ( Angewandte Chemie International Edition, February 2010)

"An essential part of the library for laboratories involved in bioinorganic and medicinal inorganic chemistry." (Chemistry World, September 2009)

Spis treści

A Basic Structural and Kinetic Aspects

1. Sequence–Selective Binding of Transition Metal Complexes to DNA

2. Thermodynamic Models of Metal Ion –DNA.Interactions

3. Metal Ion Coordination in G–quadruplexes

4. Supramolecular Chemistry of Metal–Nucleobase Complexes

B Medical Applications

5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions,

nucleotides and DNA

6. Role of DNA Repair in Antitumor Effects of Platinum Drugs

7. Telomeres and Telomerase: Potential Targets for Platinum Complexes

8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes

9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene

Expression

10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA

C DNA–Recognition – Nucleases and Sensors

11. Groove–Binding Ruthenium(II) Complexes as Probes of DNA Recognition

12. DNA Recognition and Binding by Peptide–Metal Complex conjugate

13. Artificial Restriction Agents – Hydrolytic Agents for DNA Cleavage

14. New Metallo–DNAzymes: Fundamental Studies of Metal–DNA Interactions and

Metal Sensing Applications

15. Two–metal Ion Dependent Catalysis in Nucleic Acid Enzymes

D Toxicological aspects

16. Mercury– DNA Interactions. Structural Studies on Mercury^II –Mediated T–T Base–Pair with NMR Spectroscopy

17. Chromium–Induced DNA Damage and Repair

18. Arsenic and nickel: Mechanisms Affecting DNA Integrity

O autorze

Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.

Blurb

The importance of metal–DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt ) is one of the most potent and widely used anticancer drugs in use today.

This book provides an overview of metal–DNA interactions, the mechanism of their interaction, metal–based drugs and metal ion toxicity. It is essential reading for academic researchers in bioinorganic chemistry, biochemistry, biology, biotechnology and medicine, and pharmaceutical industries involved in developing metal–based drugs.