Drug Transporters: Molecular Characterization and Role in Drug Disposition

ISBN-13: 9781119737551 / Angielski / Twarda / 2022 / 576 str.

Guofeng You; Marilyn E. Morris; Binghe Wang

Spis treści

List of ContributorsPrefaceCHAPTER 1. Overview of Drug Transporter FamiliesGuofeng You and Marilyn E. MorrisCHAPTER 2. Organic Cation and Zwitterion TransportersMegan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and KathleenM. GiacominiCHAPTER 3. Multidrug and Toxin Extrusion ProteinsLauren M. Aleksunes, Victoria Woo, and Melanie S. JoyCHAPTER 4. Organic Anion Transporters (OATs)Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. NigamCHAPTER 5. Organic Anion Transporting Polypeptides OATPRommel G. Tirona and Richard B. KimCHAPTER 6. Mammalian Oligopeptide TransportersStephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp.CHAPTER 7. Monocarboxylic Acid TransportersMarilyn E. Morris and Nisha V. KwatraCHAPTER 8. The Nucleoside Transporters CNTs and ENTsRaj Govindarajan, Antonio López Quiñones, and Joanne WangCHAPTER 9. Bile Acid TransportersEbehiremen N. Ayewoh and Peter W. SwaanCHAPTER 10. The P-glycoprotein Multidrug TransporterAndaleeb Sajid, Sabrina Lusvarghi and Suresh V. AmbudkarCHAPTER 11. Multidrug Resistance Proteins of the ABCC SubfamilyAnne T. Nies and Franziska KleinCHAPTER 12. ABCG2, the Breast Cancer Resistance Protein (BCRP)Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. BatesCHAPTER 13. Drug Transport in the LiverNoora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. BrouwerCHAPTER 14. Drug Transport in the BrainVishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina BendayanCHAPTER 15. Drug Transport in the KidneyDouglas H. SweetCHAPTER 16. Drug transporters in the human intestineStefan OswaldCHAPTER 17. Drug Transport in the PlacentaQingcheng Mao, Vadivel Ganapathy, and Jashvant D. UnadkatCHAPTER 18. Polymorphisms of drug transporters and clinical relevanceTore B. Stage and Deanna L. KroetzCHAPTER 19. Ontogeny of Drug TransportersMelanie A. Felmlee and Qing ZhangCHAPTER 20. Experimental Approaches for Studying Drug TransportersYusuke Masuo, Azusa Futatsugi, and Yukio KatoCHAPTER 21. Transporters mediated drug disposition - Physiochemistry and in silico approachesManthena V. S. Varma, Ayman El-Kattan, and Yurong LaiCHAPTER 22. In vitro-in vivo scale-up of drug transport activitiesKazuya Maeda and Yuichi SugiyamaCHAPTER 23. Application of Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling Comprising Transporters: Delineating the Role of Various Factors in Drug Disposition and ToxicityMatthew D. Harwood, Amin Rostami-Hodjegan, and Sibylle NeuhoffCHAPTER 24. Transporters as therapeutic targets in human diseasesRobert S. Jones and Eugene C. ChenCHAPTER 25. Diet/Nutrient Interactions with Drug TransportersMarilyn E. Morris and Tianjing RenIndex

O autorze

Guofeng You, PhD, Distinguished Professor of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, New Jersey, USA.Marilyn E. Morris, PhD, SUNY Distinguished Professor and Chair, Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, USA.