Disorders of the Monocyte Macrophage System: Pathophysiological and Clinical Aspects

ISBN-13: 9783540109808 / Angielski / Miękka / 1981 / 262 str.

F. Schmalzl; D. Huhn; H. E. Schaefer

Opis

The origin and function of normal monocytes and macrophages have been clearly defined by extensive investigations in human and in animal models. The central importance ofthis cell system for the biological defense mecha- nisms is well established: phagocytosis, inactivation and destruction of organic and inorganic materials, an important role in the initiation ofhumo- ral and cell mediated immunological responses, and the secretion of a varie- ty of chemical mediator and effector substances are the most important fea- tures of this ontogenetically ancient cell system. However, the data on this cellular system are rather recent, and this may explain why relatively little attention has been payed to the pathology of the monocyte-macrophage system (MMS) until now. In addition, this monograph should focus attention on the secondarypa- thophysiological implications of the MMS in disorders not primarily origi- nating from this system. Several techniques are available to identify even abnormal individuals of this cell system and, therefore, can be employed for the study of severely altered or neoplastic monocytic cells.

Spis treści

Pathophysiological Aspects.- Current View of the Mononuclear Phagocyte System.- The Kinetics of Mononuclear Phagocytes in Man.- Biochemical Properties of Human and Murine Mononuclear Phagocytes and Their Changes on Activation.- Macrophages in the Regulation of Immunity.- The Role of Macrophages as Effector Cells.- The Macrophage as a Cytotoxic Effector Cell.- The Role of Complement in the Function of the Monocyte-Macrophage System.- Macrophage-Dependent Production of Erythropoietin and Colony-Stimulating Factor.- The Relation Between Monocytes and Resident (Tissue) Macrophages.- Development of Exudate-Resident Macrophages in Vivo and in Vitro.- The Monocyte-Macrophage System in Granulomatous Inflammation.- Macrophages in Granulomas: Histochemical Evidence Suggesting Local Control of Heterogeneous Functions.- The Role of Macrophages in Storage Diseases.- Interaction of Lipoproteins with Macrophages.- The Role of Macrophages in Atherosclerosis.- Clinical Syndromes.- Acute Monocytic Leukemias.- Subacute and Chronic Myelomonocytic Leukemia.- Lysosomal Granules in Leukemic Monocytes and Their Relation to Maturation Stages.- Characteristics and Functions of Monocytes and Promonocytes in Monocytic Leukemia.- Chronic Monocytic Leukemias.- Therapy of Acute Monoblastic Leukemia.- Histiocytic Medullary Reticulosis — Neoplastic or Atypical Inflammatory Process?.- Histiocytic Medullary Reticulosis Re-visited.- Therapy of Malignant Histiocytosis.- Immunohistochemical Marking of Malignant Fibrous Histiocytoma and Malignant Histiocytosis.- Malignant Histiocytic Disorders of the Skin.- Childhood Histiocytosis X, Clinical Aspects and Therapeutic Approaches.- Therapy in Pulmonary Histiocytosis X.- Sinus Histiocytosis with Massive Lymphadenopathy and Epidural Involvement.- Familial Lymphohistiocytosis.- Concluding Remarks: The Pathology of the MMS-Present Knowledge and Future Trends.