Characterization of Compounds in Solution: Theory and Practice

ISBN-13: 9781461355083 / Angielski / Miękka / 2012 / 273 str.

William H. Streng; William H. Strenglishg

Opis

While there are many topics which can be included in a discussion on solution properties of compounds, the following are the most critical in the area of Pharmaceutics: equilibrium constants, partition coefficients, general solubility, solubility in protic solvents, and solution stability. This is the only book to address all of these areas. The purpose of this text is to bring together these topics in a logical and concise manner.

Recenzje

`One of the basic principles of physical chemistry concerns the characterization of compounds. Indeed, physical chemists make good collaborators with synthetic organic chemists in that the physikers know how to study the new compounds that the organikers continually synthesize. [...] In his short introductory chapter, the author discusses why one would want to characterize compounds, at what point during development should the compounds be characterized, and what methodologies constitute charcterization investigations. In the next two concise and tidy chapters, the authors outlines a number of basic concepts associated with themordynamics and kinetics. [...] So who should buy this book? There is no doubt that the volume constitutes an excellent source of information for graduate students because its broad focus cuts across so many fields that it can serve as a supplement to various courses. The empirical aspects will be useful to pharamceutical workers who need a shortcut to a viable experimental protocol and who do not have the time to research the literature.'
Pharmaceutical Development and Technology, 8:3 (2003)

Spis treści

Contributors. Acknowledgments. Preface. Glossary. Compound Characterization. Thermodynamics. Kinetics. Equilibrium Constants. Partition Coefficient. Solubility. Aqueous Solubility of Weak Acids and Bases. Solution Stability. Instrumentation. Equilibria: Experimental Procedures and Examples. Partitioning: Experimental Procedures and Examples. Solubility: Experimental Procedures and Examples. Solution Kinetics: Experimental Procedures and Examples. Index.