Bioactive Natural Products: Detection, Isolation, and Structural Determination, Second Edition

ISBN-13: 9780849372582 / Angielski / Twarda / 2007 / 624 str.

Colegate M. Colegate; Steven M. Colegate; Russell J. Molyneux

Opis

Following the successful format of the first edition, Bioactive Natural Products: Detection, Isolation, and Structural Determination, Second Edition presents the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. This second edition features new case studies and illustrations that demonstrate practical applications of some of the techniques covered in the book. The text includes infrared methods like Fourier transform and near infrared reflectance, ultraviolet spectroscopic methods, gas chromatography and liquid chromatography linked with mass spectrometry, combinatorial chemistry approaches, high-throughput approaches, bioactive chemical extraction, and novel bioassay development.

Spis treści

Introduction and Overview
Detection and Isolation of Bioactive Natural Products
Nuclear Magnetic Resonance Spectroscopy: Strategies for Structure Determination
Quantitative NMR of Bioactive Natural Products
Development and Application of LC-NMR Techniques to the Identification of Bioactive Natural Products
Determination of the Absolute Configuration of Bioactive Natural Products using Exciton Chirality Circular Dichroism
Separation of Enantiomeric Mixtures of Alkaloids and their Biological Evaluation
UV Dereplication of Natural Products Extracts
Liquid Chromatography-Mass Spectrometry in Natural Product Research
Application of High-Speed Counter-Current Chromatography to the Isolation of Bioactive Natural Products
Biosensing Approach in Natural Products Research
Anticancer Drug Discovery and Development from Natural Products
Sourcing Natural Products from Endophytic Microbes
Isolation of Bioactive Natural Products from Myxobacteria
Naturally-occurring Glycosidase Inhibitors
Bioassay-Directed Isolation and Identification of Anti-aflatoxigenic
Constituents of Walnuts
Bioactive Peptides in Hen Eggs
Biological Fingerprinting Analysis: Strategy for Screening of Bioactive Compounds in Traditional Chinese Medicines
Antimalarial Compounds from Traditionally-used Medicinal Plants
Germination Stimulant in Smoke:  Isolation and Identification
Plant-associated Toxins: Bioactivity-guided Isolation, Elisa and LCMS Detection

O autorze

Steven M. Colegate, Russell J. Molyneux