Advances in Enzymology and Related Areas of Molecular Biology : Protein Evolution

ISBN-13: 9780471205036 / Angielski / Twarda / 2006 / 336 str.

Eric J. Toone

Opis

Enzymes are the primary catalysts of life processes. This book covers the advances in enzymology, explaining the behaviour of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary pro

Spis treści

Contributors.

Preface.

Abstracts.

Molecular Paleoscience: Systems Biology from the Past (Steven A. Benner, Slim O. Sassi, and Eric A. Gaucher).

A Structure–Centric View of Protein Evolution, Design, and Adaptation (Eric J. Deeds and Eugene I. Shakhnovich).

Mechanisms of Protein Evolution and Their Application to Protein Engineering (Margaret E. Glasner, John A. Gerlt, and Patricia C. Babbitt).

Novel Enzymes Through Design and Evolution (Kenneth J. Woycechowsky, Katherina Vamvaca, and Donald Hilvert).

Author Index.

Subject Index.

O autorze

ERIC J. TOONE is Professor of Chemistry and Professor of Biochemistry at Duke University in Durham, North Carolina.

Blurb

Volume 75 in the classic series Advances in Enzymology and Related Areas of Molecular Biology explores the area of protein evolution. This volume considers mechanisms of protein evolution broadly, including the use of evolutionary archeology to trace protein evolution, the conservation of structure rather than sequence in protein evolution, and the use of directed evolution to create new enzyme activities.

Chapters include:

• Molecular Paleoscience: Systems Biology from the Past
• A Structure–Centric View of Protein Evolution, Design, and Adaptation
• Mechanisms of Protein Evolution and Their Applications to Protein Engineering
• Novel Enzymes Through Design and Evolution