Lymphangiogenesis in Cancer Metastasis

ISBN-13: 9789400730427 / Angielski / Miękka / 2012 / 249 str.

Steven A. Stacker; Marc G. Achen

Opis

Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells. The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi s sarcoma, and approaches for imaging lymphatics in cancer. The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis. Key Features:

• Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process
• Provides a comprehensive summary of current research in this ground breaking area
• Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise
• Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.

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Spis treści

1. LYMPHANGIOGENESIS IN HEALTH AND DISEASE – AN OVERVIEW Steven A. Stacker, Marc G. Achen, P. Haiko and K. Alitalo 2. INSIGHT INTO LYMPHATIC VASCULATURE DEVELOPMENT Nicole C. Johnson and Guillermo Oliver 3. NEW ANIMAL MODELS OF LYMPHANGIOGENESIS Benjamin M. Hogan and Stefan Schulte-Merker 4. MOLECULAR MECHANISMS OF LYMPH-NODE METASTASIS Matthias Rinderknecht and Michael Detmar 5. THE CLINICAL SIGNIFICANCE OF LYMPH-NODE METASTASIS Mark B. Faries and Donald L. Morton 6. CLINICOPATHOLOGICAL ANALYSIS OF LYMPHATIC VESSELS AND OF LYMPHANGIOGENESIS IN HUMAN CANCER Ilse Van der Auwera, Peter B Vermeulen and Luc Y Dirix 7. LYMPHANGIOGENESIS AND IMAGING OF THE LYMPHATICS IN CANCER Baris Turkbey, Gregory Ravizzini, Peter L. Choyke, and Hisataka Kobayashi 8. LYMPHANGIOLEIOMYOMATOSIS Kuniaki Seyama, Toshio Kumasaka, Teruhiko Sato and Keiko Mitani 9. KAPOSI’S SARCOMA AND THE LYMPHATICS Victoria Emuss and Chris Boshoff 10. LYMPHATIC PHYSIOLOGY AND FUNCTION IN HEALTHY TISSUE AND CANCER Jacqueline D. Shields and Melody A. Swartz