Written by experts worldwide, this book provides the current knowledge of growth factors and their receptors in cancer metastasis. It covers basic cellular and molecular biology of growth factors and their receptors, as well as their role in cancer and cancer metastasis in clinical settings. The book is intended for cancer biologists, cell biologists, biochemists, geneticists, oncologists, surgeons and physicians. It is also a valuable reference for those who work in the area of cancer research, cancer therapies, cancer care, pharmaceutical industry. Postgraduates and undergraduates who...
Written by experts worldwide, this book provides the current knowledge of growth factors and their receptors in cancer metastasis. It covers basic cel...
Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.
Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.
Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disea...
Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.
Once cancer cells...
Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tr...
Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding...
Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout t...
Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights....
Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enab...
The ability of an epithelial cell to adhere to its neighbor and to the extracellular environment is an essential process that defines in part a normal multicellular organism. In the post-genomic era of cancer biology, it is known that epithelial tumors are multi-clonal and are genetically unstable. In contrast, during the process of tumor metastasis, which is the major cause of death from cancer, a restricted set of adhesion molecules are displayed on the tumor cell surface. The adhesion molecules provide a selective advantage for migration of the tumor cell to a distant site. In this...
The ability of an epithelial cell to adhere to its neighbor and to the extracellular environment is an essential process that defines in part a nor...
Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells.
The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi s sarcoma,...
Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship ...
Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.
Once cancer cells...
Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tr...
